过渡和成熟人乳中的微生物群的组成:对于妊娠年龄组的大规模显著变化
Meltem Dinleyici1, Vicente Pérez-Brocal2,3, Sertac Arslanoglu4
1Department of Social Pediatrics, Faculty of Medicine, Eskisehir Osmangazi University, 26480 Eskisehir, Türkiye.
Nutrients
|January 23, 2024
概括
人类母乳微生物群的组成因母体因素和婴儿大小而有所不同. 对于妊娠年龄大 (LGA) 的婴儿在母乳中显示出主导的Ralstonia,Burkholderiaceae_uc和Pelomonas,无论哺乳期如何.
科学领域:
- 微生物学 微生物学
- 人类牛奶的成分 人类牛奶的成分
- 婴儿营养 婴儿营养
背景情况:
- 人类牛奶 (HM) 微生物群受到母亲的健康,饮食,分娩方式和婴儿养的影响.
- 了解HM微生物群的变化对于婴儿的健康和发育至关重要.
- 诸如妊娠年龄和出生体重等因素可以影响HM微生物组成.
研究的目的:
- 为了比较44名婴儿母亲的短暂和成熟的HM微生物群.
- 调查与早产,分娩方式和出生体重相关的HM微生物群变化.
- 分析五个婴儿群体的微生物差异:正常自发分娩期 (NS-T),剖腹产期 (CS-T),早产期 (PT),妊娠年龄小 (SGA),妊娠年龄大 (LGA).
主要方法:
- 收集过渡性 (产后7-15天) 和成熟的 (产后45-90天) HM样本.
- 根据妊娠年龄和出生体重将母亲/婴儿分为五个研究组.
- 利用ANCOM-BC进行微生物属在HM样本中的差异丰度分析.
主要成果:
- 在采样时间和研究组之间观察到HM微生物群的显著差异 (p < 0.01).
- 拉尔斯托尼亚,Burkholderiaceae_uc和Pelomonas在短暂和成熟的HM中在妊娠年龄大 (LGA) 组中显著占主导地位.
- 在CS-T,PT,SGA和LGA组中观察到过渡和成熟样本之间的HM微生物群差异,但在NS-T组中没有.
结论:
- 拉尔斯托尼亚,Burkholderiaceae_uc和Pelomonas在LGA婴儿的母亲的HM中始终占主导地位.
- 孕妇的BMI和怀孕期间的体重增加在LGA组中更高.
- 需要进一步研究HM微生物群对婴儿肠道微生物群和健康结果的影响.
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