对工艺参数对基于聚乙烯 (Vinyl) 酒精的涂层系统稳定性的影响的研究
Viviana Claudia Canale1, Lorenzo Paleari2, Mario Bragaglia2
1Department of Chemical Science and Technologies, University of Rome 'Tor Vergata', Via della Ricerca Scientifica, 00133 Rome, Italy.
Molecules (Basel, Switzerland)
|January 23, 2024
概括
这项研究调查了紫外线,热量和湿度等环境因素如何影响基于PVA的平板电脑涂层. 分析了二氧化和氧化等关键成分对它们在应力下对涂层性能的影响.
科学领域:
- 制药科学 制药科学
- 聚合物科学 聚合物科学
- 材料科学 材料科学 材料科学
背景情况:
- 大多数商用药片使用水溶性聚合物涂层用于各种制药应用.
- 基于聚乙醇 (PVA) 的涂料,如Colorcon的Opadry II 85系列,自20世纪90年代以来已被广泛使用.
- 关于影响这些基于PVA的涂料的长期性能的特定物理化学参数的研究有限.
研究的目的:
- 评估关键环境因素 (紫外线,高温,相对湿度) 对基于PVA的平板电脑涂料性能的影响.
- 分析关键配方成分,包括二氧化和氧化,在人工老化过程中对涂层稳定性的影响.
- 了解Opadry Orange II在各种压力条件下的降解机制和性能变化.
主要方法:
- 采用人工老化过程来模拟涂层样本的环境应力.
- 采用了多学科的分析方法,包括里埃变换红外光谱 (FTIR),核磁共振 (NMR),风学和动态机械热分析 (DMTA).
- 涂层样本及其单个组件的物理化学特性在老化前后进行了评估.
主要成果:
- 该研究确定了Opadry Orange II及其组件在紫外线,高温和高湿度下物理化学性质的特定变化.
- 分析揭示了二氧化和氧化如何与PVA矩阵相互作用,并影响涂层对老化的反应.
- 使用先进的分析技术,描述了降解途径和机械和粘弹性质的变化.
结论:
- 环境因素对基于PVA的平板电脑涂料的性能和稳定性产生重大影响.
- 诸如二氧化和氧化等辅助剂的选择和度在涂层抗衰老能力方面发挥着至关重要的作用.
- 这项研究为优化制药涂层配方提供了宝贵的见解,以确保长期药物产品的稳定性和有效性.
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