橄香精油的化学成分,以及抗氧化和抗菌活性
Magdalena Walasek-Janusz1, Agnieszka Grzegorczyk2, Anna Malm2
1Department of Vegetable and Herb Crops, Faculty of Horticulture and Landscape Architecture, University of Life Sciences in Lublin, 51A Doświadczalna Street, 20-280 Lublin, Poland.
Molecules (Basel, Switzerland)
|January 23, 2024
概括
富含卡瓦克罗尔的橄香精油 (OEOs) 显示出强大的抗微生物和抗氧化活性. 这些天然化合物,特别是来自波兰的OEO,显示出作为对抗耐药细菌和真菌的替代剂的巨大潜力.
科学领域:
- 植物化学 植物化学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗菌素耐药性 (AMR) 是一个日益严重的全球卫生危机,由过度使用抗生素驱动.
- 天然产品,如香精油 (OEOs),正在作为替代抗菌剂进行研究.
- Oregano 精油 (OEO) 含有具有潜在治疗功能的生物活性化合物.
研究的目的:
- 分析来自四个不同的地理来源 (波兰,欧洲,土耳其,美国) 的OEOs的化学成分.
- 评估这些OEO对格兰阳性细菌,格兰阴性细菌和Candida物种的抗菌活性 (AMA).
- 用DPPH方法确定OEOs的抗氧化活性 (AA).
主要方法:
- 气色谱-质谱 (GC-MS) 用于化学成分分析.
- 微稀释方法用于确定抗微生物活性的最小抑制度 (MIC).
- DPPH测定量化抗氧化能力.
主要成果:
- 卡瓦克罗尔是所有测试的OEO中占主导地位的化合物,在76.64%至85.70%之间,在波兰OEO中发现的度最高.
- 经过OEO的检测,OEO表现出显著的抗菌活性,特别是针对真菌菌株 (MIC = 0.06-0.25 mg/mL).
- 观察到高抗氧化活性,值在71.42%至80.44%之间.
结论:
- Oregano 精油,特别是那些含有高卡瓦克罗尔的精油,具有显著的抗微生物和抗氧化特性.
- 这些发现表明,OEOs是作为天然治疗剂进一步研究和开发的有希望的候选人.
- 地理来源影响化学成分,特别是卡瓦克罗尔水平,影响OEO的疗效.
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