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通过顺序注射分析确定N-乙-L-氨酸乙烯 Ester (NACET)

Lea Kukoc-Modun¹, Tomislav Kraljevic², Dimitrios Tsikas³

¹Department of Analytical Chemistry, Faculty of Chemistry and Technology, University of Split, Ruđera Boškovića 35, 21000 Split, Croatia.

Sensors (Basel, Switzerland)

|January 23, 2024

概括

使用顺序注射分析 (SIA) 和光学传感的新方法可以准确地确定N-乙-L-氨酸乙烯 (NACET). (II) -BCS复合体对这种潜在药物显示出最佳的灵敏度和采样率.

科学领域:

分析化学分析化学
药品分析药品分析
频谱光度测量是一种光谱光度测量.

背景情况:

N-乙-L-氨酸乙烯 (NACET) 是一种有前途的药物和抗氧化剂,具有有利的药理学特性.
准确而敏感的分析方法对于NACET的质量控制和治疗监测至关重要.

研究的目的:

开发和优化新的顺序注入分析 (SIA) 方法来定量确定NACET.
评估不同铜 (II) 复合物的性能,作为用于NACET检测的光学传感器.

主要方法:

开发利用光学传感用于NACET测定的SIA系统.
使用铜 (II) 复合物与新库普罗因 (NCN),双酸 (BCA) 和巴托库普罗因二硫酸 (BCS) 作为传感剂.
优化每个传感系统的多种参数和实验条件,测量特定波长的吸收度 (NCN为458nm,BCA为562nm,BCS为483nm).

主要成果:

所有开发的SIA方法都表现出良好的线性,校准范围根据使用的复杂性而有所不同.
铜(II) - 巴托库普洛因二硫酸 (BCS) 复合体表现出最低检测极限 (2.6 × 10−6 mol L−1) 和最高采样率 (78 h−1).
药品配方中常见的辅助剂不会干扰NACET分析,这表明方法的特异性.

结论:

开发的SIA方法为NACET的确定提供了灵敏而高效的手段.
基于Cu (II) -BCS复合的方法由于其更高的灵敏度和采样速度,特别有利.
这些方法适用于药品制剂中NACET的分析.

关键词:

这是一种N-乙-L-氨酸乙烯 (NACET)巴托库普罗因二硫酸 (BCS) 是一种双辛酸 (BCA) 是一种双辛酸.新库普罗因 (NCN) 是一种新型的蛋白质.顺序注射分析 (SIA) 是指一个连续注射分析.

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