首次感染SARS-CoV-2对人类Anellovirus的影响
Anne L Timmerman1,2, Lisanne Commandeur1,2, Martin Deijs1,2
1Laboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Viruses
|January 23, 2024
概括
在血液中常见的anelloviruses在二次SARS-CoV-2感染期间暂时减少. 免疫系统的激活会对这些病毒产生影响,荷载在几周内恢复正常.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 人类微生物组 人类微生物组
背景情况:
- 类病毒家族的病毒在人类血液病毒组中普遍存在.
- 他们的负载在成年人中通常是稳定的,但受免疫状况的影响.
- 急性二次感染对anellovirus负载的影响以前是未知的.
研究的目的:
- 为了研究二次感染,特别是SARS-CoV-2对血液中的anellovirus负载的影响.
- 了解感染期间的免疫激活是否会改变瘤 (各种瘤病毒).
主要方法:
- 在3个月内,从19名感染SARS-CoV-2的医疗保健工作者 (HCW) 和27名对照者收集了血清样本.
- 使用定量聚合酶连锁反应 (qPCR) 量化Anellovirus负载.
- 在一小部分参与者中,使用Illumina测序分析了Anellome组成.
主要成果:
- 在SARS-CoV-2感染的几周内,HCW观察到血清anellovirus负载的显著下降.
- 在未感染的对照组中,anellovirus度保持稳定.
- 瘤分析显示,感染期间五个HCW中的三个发生了变化,其中两个恢复到基线.
- 在SARS-CoV-2感染后大约10周内,出现了Anellovirus负载的恢复.
结论:
- 像SARS-CoV-2这样的急性二次感染可以暂时降低血液中的anellovirus负载.
- 这表明,对感染的免疫反应可以调节anellovirus平衡.
- 在对系统性免疫激活的反应中,瘤可能会表现出动态变化.
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