动物和体外模型作为强大的工具来解读肠道病原体对人类肠道微生物群的影响
Marco Calvigioni1, Diletta Mazzantini1, Francesco Celandroni1
1Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56127 Pisa, Italy.
Microorganisms
|January 23, 2024
概括
了解肠道病原体如何影响肠道微生物群是人类健康的关键. 本综述总结了使用动物和体外模型的病原体影响,这对于研究肠道健康和疾病至关重要.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 肠道病原体显著影响肠道微生物群的组成和功能.
- 了解这些相互作用对于人类健康和疾病的发病过程至关重要.
- 实验室模型对于研究病原体-宿主-微生物群动态至关重要.
研究的目的:
- 审查主要人类肠道病原体对肠道微生物群落的影响.
- 强调动物和体外模型研究的发现.
- 探索对肠道功能和健康的转化影响.
主要方法:
- 对肠道病原体-肠道微生物群相互作用的现有文献的审查.
- 专注于利用肠道感染动物模型的研究.
- 包括使用先进的人体肠道体外模型的研究.
主要成果:
- 总结了关键病原体的影响,包括*Clostridioides difficile*, *Campylobacter jejuni*, 腹致病的*Escherichia coli*, *Salmonella enterica*, *Shigella*物种, *Vibrio cholerae*和 *Bacillus cereus*.
- 突出了动物模型如何为我们了解病原体诱导的失生症提供信息.
- 讨论了模仿肠道环境的体外系统所获得的见解.
结论:
- 动物和体外模型为病原体诱导的肠道失调提供了宝贵的见解.
- 这些模型对于理解病原体作用和开发治疗策略至关重要.
- 使用这些模型进行进一步的研究将有助于我们更好地了解肠道健康和疾病.
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