大肠杆菌的特征从表现出性 Vulvar 排泄的母猪中分离出来的大肠杆菌
André P Poor1, Luisa Z Moreno1, Matheus S Monteiro1
1Department of Preventive Veterinary Medicine and Animal Health, School of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Dr. Orlando Marques de Paiva 87, São Paulo 05508-270, SP, Brazil.
Microorganisms
|January 23, 2024
概括
致病性大肠杆菌引起的母猪的生殖尿路感染导致了严重的经济损失. 这些大肠杆菌菌株表现出高抗微生物耐药性,并拥有毒性基因,突出了对猪健康的担忧.
科学领域:
- 兽医微生物学 兽医微生物学
- 猪健康 猪健康
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 猪的性阴道泄漏表明生殖尿路感染,是猪杀和死亡的主要原因.
- 大肠杆菌是这些感染的主要病原体,对猪生产构成重大威胁.
研究的目的:
- 描述毒性因子,抗菌素耐药性模式,以及来自有性阴道泄漏的母猪的大肠杆菌菌株的类型.
- 了解这些与猪相关的大肠杆菌病原性和耐药性的遗传基础.
主要方法:
- 从有性漏的母猪中分离和识别大肠杆菌.
- 检测了29个与肠外病原体大肠杆菌相关的毒性基因.
- 大肠杆菌菌株的分类.
- 抗微生物敏感性测试.
主要成果:
- 所有测试的菌株都含有至少两个毒性基因,其中iutA是最常见的.
- 铁的吸收,粘附,血清耐药性,毒素释放和细菌素基因之间经常观察到联系.
- 类型B1是最常见的 (40.0%),其次是A (18.5%),D (11.9%) 和C (9.6%). 类型B2菌株表现出高度毒性特征.
- 超过90%的菌株具有多药耐药性,对西普洛克萨,链杆菌素,塞法莱克辛,佛罗芬尼科尔和安皮西林的耐药性提高.
结论:
- 来自有性漏的母猪的大肠杆菌菌株具有显著的毒性潜力和广泛的多药性耐药性.
- 抗微生物药物耐药性的高流行率表明,在养猪业中广泛使用抗微生物药物的选择压力.
- 这些发现强调了需要在猪生产中改进抗菌管理和感染控制策略的必要性.
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