在SARS-CoV-2之后肠道微生物组的破坏:一篇评论
Elda Righi1, Ilaria Dalla Vecchia1, Nina Auerbach1
1IMID Laboratory, Department of Diagnostics and Public Health, Infectious Diseases Division, University of Verona, 37134 Verona, Italy.
COVID-19对肠道微生物组产生负面影响,减少有益细菌和增加病原体. 这些微生物组变化在感染后持续存在,可能会影响长期健康,并需要进一步研究针对性疗法.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
背景情况:
- COVID-19与活跃感染期间和急性后阶段的显著肠道微生物组失调有关.
- 改变包括减少有益的共生体 (例如,Roseburia) 和增加机会性病原体 (例如,Enterococcus,Proteobacteria).
- 观察到阿尔法多样性的减少,特别是在症状发作和住院期间.
研究的目的:
- 调查COVID-19对肠道微生物组合和多样性的影响.
- 探索肠道微生物组在后急性阶段变化的持续性及其与临床结果的关联.
- 确定潜在的治疗策略,例如基于益生菌的干预措施.
主要方法:
- 分析急性和后急性COVID-19患者的肠道微生物组组成和多样性.
- 微生物组特征与疾病严重程度,临床康复和呼吸功能的相关性.
- 审查潜在的混因素和未来的研究方向.
主要成果:
- 在急性COVID-19中观察到的快速肠道微生物组变化,其特点是有益细菌减少和病原体增加.
- 肠道平衡的恢复可能需要数周的时间,即使在轻微的情况下.
- 在COVID-19后综合征患者中发现了持续的微生物组变化,与感染后长达12个月的呼吸功能减弱有关.
结论:
- COVID-19深刻影响肠道微生物群,在后急性阶段观察到持久的改变.
- 了解这些微生物组的动态对于阐明COVID后综合征的发病过程至关重要.
- 需要进一步的研究来探索基于微生物组的诊断和个性化治疗干预措施.
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