可口味性和稳定性研究,以优化儿童使用的卡维迪洛尔口服液体配方
Blanca Chiclana-Rodríguez1, Encarnacion Garcia-Montoya1,2, Miquel Romero-Obon1
1Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII, 27-31, 08028 Barcelona, Spain.
Pharmaceutics
|January 23, 2024
概括
在儿童心血管疾病治疗中,开发可口的卡维迪醇 (CARV) 液体配方至关重要. 这项研究成功地创造了稳定,美味的CARV液体,改善了患者的接受度.
科学领域:
- 制药科学 制药科学
- 儿科药理学 儿科药理学
- 药物的配方 药物的配方
背景情况:
- 卡维迪醇 (CARV) 是一种α和β阻塞剂,用于治疗儿科心血管疾病.
- 需要一种适合儿科的CARV液体配方,因为目前没有一种在市场上销售.
- 可口味性对于儿科配方的接受至关重要,直接影响了坚持和治疗结果.
研究的目的:
- 开发和评估用于儿科的新型CARV液体配方的可口性和可接受性.
- 为了确定最佳的CARV配方,增强口味和气味的特征.
- 评估所选CARV配方的物理化学和微生物稳定性.
主要方法:
- 用不同度的调味剂和甜味剂 (糖) 制备CARV溶液.
- 在体内味道评估使用成年志愿者通过问卷和感官测试来评估口味和感官属性.
- 在各种温度条件下 (25°C,30°C,40°C) 测试优化配方的稳定性6个月,在25°C下使用稳定性15天.
主要成果:
- 味道性得分从1.60 (无味) 显著增加到7.65 (优化的调味配方) 在10分级上.
- 苦味从66.67%降低到17.86%,口感愉悦度从25/100提高到73/100在优化的配方中.
- 优化的CARV液体配方在6个月的时间内以及在使用条件下显示出确定的物理化学和微生物稳定性.
结论:
- 一种适合儿科使用的可口且稳定的卡维迪醇液体配方已成功开发出来.
- 优化的配方包括适合儿科的辅助剂,包括糖和特定的调味剂.
- 这一发展解决了儿童患者对可接受和稳定的CARV口服溶液的关键未满足需求.
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