微针辅助转移体作为阿司匹林的通过皮肤输送系统
Raha Rahbari1, Lewis Francis1, Owen J Guy2
1Centre for Nanohealth, Institute of Life Science 2, Swansea University Medical School, Swansea SA2 8PP, UK.
Pharmaceutics
|January 23, 2024
概括
这项研究引入了一种新的透皮药物输送系统,将转移体与微针结合起来,以提高阿司匹林的输送效果. 该系统显著改善了通过皮肤的药物透,为全身药物管理提供了一个有希望的替代方案.
科学领域:
- 制药科学 制药科学
- 生物材料工程 生物材料工程
- 药物输送系统 药物输送系统
背景情况:
- 通过皮肤递送药物提供了诸如避免第一通代谢和患者方便等优势.
- 传统方法在药物溶解性和受控释放方面面临挑战.
- 需要新的系统来增强药物透和疗效.
研究的目的:
- 开发和描述一种新的阿司匹林通过皮肤递送药物系统.
- 为了评估转移体与微针相结合的转移体的疗效,以提高通过皮肤透的效果.
- 评估开发系统的药物释放特征和细胞毒性.
主要方法:
- 阿司匹林被封装在转移体中,使用薄膜水化声波.
- 转移体的特点是大小,电荷和稳定性.
- 转移体与或聚碳酸微针相结合,用于猪皮肤的透性研究.
- 光学连贯断层扫描 (OCT) 和传输电子显微镜 (TEM) 用于表征.
- 在实验室中进行了透和细胞毒性研究.
主要成果:
- 高封装效率 (大约) 在转移组中,阿司匹林达到67.5%的水平.
- 单独的转基因增强了阿司匹林的透性,与自由阿司匹林相比增加了四倍以上.
- 微针辅助分娩显著增加了透率,比单独的转移体增加了13倍 () 和10倍 (聚碳酸).
- 封装阿司匹林在度≥100μg/mL时显示出细胞毒性.
- 该系统展示了控制释放低水溶性药物的潜力.
结论:
- 开发的转移体微针系统有效地增强了通过皮肤递送药物的效果.
- 这种组合克服了药物溶解性问题,并使控制释放成为可能.
- 微针方便更深的皮肤透,改善全身药物输送.
- 该系统具有各种治疗应用的潜力.
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