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通过新抗原mRNA疫苗对ICI的有效性进行敏感化,用于HCC治疗

Rui Han1,2,3,4, Yuqian Wang1,2, Lingeng Lu4,5,6

  • 1Department of Chinese Medicine Oncology, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China.

Pharmaceutics
|January 23, 2024
PubMed
概括

下一代信使RNA (mRNA) 癌症疫苗显示出免疫治疗的前景,基于COVID-19疫苗的成功. 将mRNA疗法与免疫检查点抑制剂相结合,为治疗和预防肝细胞癌提供了新的希望.

关键词:
在HCC中,HCC是HCC,HCC是HCC.综合疗法 综合疗法免疫检查点抑制剂免疫检查点抑制剂新抗原mRNA疫苗的使用.这是一个新的治疗策略.

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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