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基于天然生物聚合物的CRISPR/Cas9输送用于癌症治疗

Meng Lin¹, Xueyan Wang¹

¹Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China.

|January 23, 2024

概括

自然生物聚合物为提供CRISPR/Cas9基因编辑工具提供了一个有前途的解决方案,增强癌症治疗. 这些材料提高了稳定性和效率,克服了临床应用的关键交付挑战.

科学领域:

生物材料科学生物材料科学
基因编辑技术基因编辑技术
癌症治疗方法癌症治疗方法

背景情况:

聚类,定期间隔的短平行列重复 (CRISPR) /CRISPR相关蛋白9 (Cas9) 系统是治疗疾病,特别是癌症的领先基因编辑工具.
有效地传递CRISPR/Cas9 (作为DNA,mRNA或核糖蛋白) 仍然是临床翻译的一个重大障碍.
纳米材料正在开发中,以提高CRISPR/Cas9系统的稳定性和传递效率.

研究的目的:

审查基于天然生物聚合物的材料在癌症治疗中用于CRISPR/Cas9传递的进展.
突出自然生物聚合物的优点,包括稳定性,低毒性和生物相容性.
讨论与这些传递系统的临床翻译相关的挑战.

主要方法:

文献综述侧重于用于CRISPR/Cas9传递的天然生物聚合物应用.
对基因编辑传递 (稳定性,毒性,生物相容性) 有关材料性质的分析.
检查专门针对癌症应用的研究.

主要成果:

自然生物聚合物显示出作为CRISPR/Cas9系统的载体的巨大潜力.
与其他输送方法相比,这些材料提供了更好的稳定性,生物相容性和生物降解性.
在临床前癌症模型中报告了成功的应用.

结论:

基于天然生物聚合物的载体代表了在癌症治疗中推进CRISPR/Cas9基因编辑的有希望的策略.
克服交付挑战对于实现CRISPR/Cas9.9的全部临床潜力至关重要.
需要进一步的研究来解决成功临床翻译的剩余挑战.

关键词:

这就是CRISPR/Cas9的作用.基因传递基因传递基因传递天然生物聚合物的生物聚合物.瘤治疗的治疗方法

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