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通过将机械干涂层和超声波振动相结合,通过颗粒聚合提高吸入性能
Qingzhen Zhang1, Zheng Wang1,2, Kaiqi Shi3
1Department of Chemical and Environmental Engineering, University of Nottingham Ningbo China, Ningbo 315100, China.
Pharmaceutics
|January 23, 2024
概括
用表面修改的乳糖聚合物和超声波振动改善布德索尼德干粉吸入 (DPI) 配方,提高了气溶的性能. 这种方法可以减少上呼吸道沉积和潜在的副作用,以获得更好的治疗结果.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 干粉吸入 (DPI) 的聚合物配方对于有效的布塞索尼德输送至关重要.
- 不受控制的聚合会导致高上呼吸道沉积,局部副作用和细颗粒传递不良.
研究的目的:
- 通过表面修饰和超声波球化来改善布索尼德聚合物的气溶性能.
- 降低聚合物中的机械强度和凝聚力,以增强脱聚和细颗粒分离 (FPF).
主要方法:
- 精细的乳糖颗粒被机械干覆盖,用疏水性酸.
- 随后,聚合物通过超声波振动进行球状化.
- 使用Turbuhaler®和制药级联冲击器评估了气溶的性能.
主要成果:
- 优化的聚合物表现出较低的机械强度和减少的凝聚力.
- 观察到改善了细粉的分散行为.
- 达到了71.1 ± 1.3%的高微粒分数 (FPF) 和19.3 ± 0.4%的低人工喉沉积.
结论:
- 用酸和超声波振动对表面进行修改,显著增强了布松酸聚合物气溶化.
- 这一策略有可能提高治疗疗效,减少口腔和喉的局部副作用.
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