交叉链接的酸二甲基/酸水凝,包括含黄素的双体体,增强伤口愈合活性
Sarah A Sideek1, Hala B El-Nassan2, Ahmed R Fares1
1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
Pharmaceutics
|January 23, 2024
概括
这项研究开发了一种含有黄素的双体凝,用于有效的局部伤口愈合. 这种新型配方在动物研究中表现出卓越的性能,提供了一个有前途的新治疗方案.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 黄素具有较差的水溶性和较低的口服生物可用性,限制了其治疗应用.
- 开发有效的药物输送系统对于提高黄素的疗效至关重要.
- 比洛索姆和水凝为局部药物输送和伤口管理提供了潜力.
研究的目的:
- 制造和表征含有黄素的双胞体水凝,用于局部伤口愈合.
- 为了克服黄素的可溶性和生物利用性的局限性.
- 评估开发的配方在伤口愈合模型中的有效性.
主要方法:
- 用胆固醇,Span® 60和胆汁盐 (脱氧酸盐或胆汁盐) 用薄膜水化技术制备了双体体.
- 优化的双体体因粒子大小,PDI,ZP和捕获效率而具有特征.
- 为进一步评估,加载黄素的双体体被纳入酸盐二甲基/酸盐水凝中.
主要成果:
- 优化的双细胞体配方显示出有利的特征,包括颗粒大小为246.25±11.85nm和高捕获效率 (93.32%±0.40).
- 装载的水凝在五天内持续释放药物,并具有高吸水能力 (729.50%±43.13).
- 在体内研究表明,伤口在三周内完全关闭,与对照组相比,观察到更好的愈合.
结论:
- 含有黄素的双胞体水凝是一种稳定有效的局部剂型,用于伤口愈合.
- 该配方通过改善黄素的输送和有效性来增强黄素的治疗潜力.
- 这种新的水凝代表了伤口护理管理的有希望的进步.
相关概念视频
01:01Acid Halides to Carboxylic Acids: Hydrolysis
Hydrolysis of acid halides is a nucleophilic acyl substitution reaction in which acid halides react with water to give carboxylic acids. The reaction occurs readily and does not require acid or a base catalyst.
As shown below, the mechanism involves a nucleophilic attack by water at the carbonyl carbon to form a tetrahedral intermediate. This is followed by the reformation of the carbon–oxygen π bond along with the departure of a halide ion. A final proton transfer step yields carboxylic acid...
As shown below, the mechanism involves a nucleophilic attack by water at the carbonyl carbon to form a tetrahedral intermediate. This is followed by the reformation of the carbon–oxygen π bond along with the departure of a halide ion. A final proton transfer step yields carboxylic acid...
01:23Glycosaminoglycans
Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino sugar that can be N-acetylglucosamine or N-acetylgalactosamine, and a uronic acid that is usually glucuronic acid or iduronic acid.
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
01:27Acids, Bases and Neutralization Reactions
Acids and bases play several important roles in biology. The pH of a biological system can significantly impact the function of biological molecules, including enzymes, proteins, and nucleic acids. For example, enzymes have optimal pH ranges for their activity, and changes in pH can denature or alter their structure, affecting their function. Acids and bases also play a crucial role in cellular signaling and communication. The pH of the extracellular fluid around cells can influence the...
01:24Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
01:21Acid Attack on Concrete
When acids come into contact with concrete, they initiate a chemical reaction that dissolves the hydrated cement paste. This process leads to softening and structural weakening of the concrete. This issue is commonly observed in environments such as chimneys, sewers, and industrial settings. The severity of the damage increases as the pH of the water interacting with the concrete drops below 6.5. In particular, a pH under 4.5 can cause significant concrete damage.
The rate at which hydrogen...
The rate at which hydrogen...
01:24Healing II: Complications
Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...