在胰腺癌治疗中使用gemcitabine-Vitamin E Prodrug-loaded Micelles
Miguel Pereira-Silva1,2,3, Darío Miranda-Pastoriza4,5, Luis Diaz-Gomez3
1Department of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, 3000-548 Coimbra, Portugal.
Pharmaceutics
|January 23, 2024
概括
这项研究开发了在胰腺癌中用于凝胺 (GEM) 的新型纳米颗粒药物递送系统. 这些维生素E酸盐-GEM前菌体显示了提高疗效和降低毒性,改善了癌症治疗.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 在瘤学瘤学.
背景情况:
- 胰腺癌 (PC) 由于凝胺 (GEM) 的局限性而带来了重大治疗挑战.
- GEM的水友性阻碍了其在纳米载体中的封装,阻碍了有效的药物输送.
- 需要新的策略来改善GEM的稳定性,向性和减少系统毒性.
研究的目的:
- 开发和表征基于Pluronic®的纳米细胞,封装一个维生素E酸盐-GEM原药 (VES-GEM).
- 提高GEM在胰腺癌治疗中的疗效和安全性.
- 研究纳米载体的物理化学特性和生物性能.
主要方法:
- 合成VES-GEM前药物,并将其纳入Pluronic® F68和F127小粒.
- 微粒大小,电荷,形态和封装效率 (>95%) 的表征.
- 评估药物释放动力学,稳定性,血液兼容性和体外抗癌疗效.
主要成果:
- 装有VES-GEM的粒显示了高封装效率和可接受的颗粒大小.
- 普鲁罗尼克® F127/VES-GEM菌株表现出优越的药物释放,稳定性和细胞内化.
- 观察到显著抑制瘤细胞生长和改善血液兼容性.
结论:
- 带有VES-GEM合物载的Pluronic®片为增强胰腺癌治疗提供了一个有前途的纳米载体系统.
- 这种方法提高了GEM的疗效和安全性,解决了传统化疗的局限性.
- 开发的纳米细胞是瘤学中向药物输送的可行策略.
关键词:
化疗 化疗是一种化学疗法.药物输送是药物输送的过程.辅助剂的减少减少.杰姆西塔宾 (gemcitabine) 是一种药物.纳米粒子是一种纳米粒子.胰腺癌是一种癌症.聚合物米塞尔 (Micelle) 是一种聚合物.药物前体是药物前体.维生素E联合酸更多相关视频
07:32Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
11.3K
08:35Therapeutic Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-targeted Gelatin Nanoparticles
Published on: January 4, 2012
28.3K
相关概念视频
01:15Drugs that Stabilize Microtubules
2.0K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.0K
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K