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临床实践中的精准医学:在血中确定阿里皮普拉的Alinity C与UHPLC-MS/MS

Francisco José Toja-Camba^1,2,3, Enrique Bandín-Vilar^1,2,3, Gonzalo Hermelo-Vidal²

¹Pharmacy Department, University Clinical Hospital of Santiago de Compostela (SERGAS), 15706 Santiago de Compostela, Spain.

|January 23, 2024

概括

超高性能液体染色学-并联质谱学 (UHPLC-MS/MS) 和Alinity C系统在测量抗精神病药物水平方面显示出良好的一致性. 然而,在15%的病例中,方法选择可能会影响临床决策.

科学领域:

临床化学临床化学
药理学药理学是指药理学的学科.
分析化学分析化学

背景情况:

治疗药物监测 (TDM) 对于优化抗精神病治疗至关重要.
超高性能液态染色学-并联质谱学 (UHPLC-MS/MS) 是TDM的黄金标准.
艾利尼蒂C系统为药物度分析提供了一个潜在的替代方案.

研究的目的:

本研究首先将Alinity C系统与UHPLC-MS/MS进行比较,用于测量阿里皮普拉和脱水阿里皮普拉的血度.
为了评估这些测量的Alinity C系统的可重现性.

主要方法:

使用UHPLC-MS/MS和Alinity C.两种方法分析了86个血样本.
使用Spearman的相关性和McNemar的测试来评估试验一致性.
通过巴布洛克回归分析了方法的相关性和偏差.
通过在6个月后重新分析26个样本来评估Alinity C的可重复性.

主要成果:

在UHPLC-MS/MS和Alinity C.之间观察到强烈的相关性 (rs = 0.96).
在治疗范围内的样品分类方面没有发现显著差异.
通过巴布洛克回归显示出良好的相关性 (rs = 0.93),与Alinity C产生更高值的轻微趋势.
单性C显示出优异的可重复性 (rs = 0.99).
根据使用的方法,在15%的病例中,临床决定可能会有所不同.

结论:

艾利尼蒂C系统为UHPLC-MS/MS提供了一种可靠的替代方案,用于对阿里皮拉和脱水阿里皮拉的监测.
虽然通常可以比较,但不同的临床决策的可能性需要仔细考虑所选择的分析方法.
在抗精神病药物水平测量方面,Alinity C系统表现出良好的可重现性.

关键词:

结合性 C 结合性 C 时间 TDM TDM 在UHPLC-MS/MS中使用.亚利皮普拉 (aripiprazole) 是一种药物.监控监控监控监控监控监控

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