探索Fasudil化的眼睛吸收途径,以开发具有提高性能的纳米颗粒配方
Barzan Osi1, Ali A Al-Kinani1, Zinah K Al-Qaysi1
1Drug Discovery, Delivery and Patient Care (DDDPC) Theme, School of Life Sciences, Pharmacy and Chemistry, Kingston University London, London, KT1 2EE, UK.
Pharmaceutics
|January 23, 2024
概括
一种青光眼药物法苏迪尔化物显示出角膜吸收不良. 素纳米颗粒改善了它的角膜透性,并显示出良好的眼睛生物相容性,提供了一个有前途的输送系统.
科学领域:
- 眼科医生 眼科 眼科
- 纳米技术纳米技术
- 药理学 药理学是指药理学的学科.
背景情况:
- 罗基纳酶 (ROCK) 抑制剂,如法苏迪尔化,是一种新型的抗白内障药物.
- 阻断ROCK通路对于调节水性幽默外流至关重要.
- 了解Fasudil的眼睛吸收是有效治疗青光眼的关键.
研究的目的:
- 研究法苏迪尔化的眼部吸收途径.
- 开发一种素纳米粒子 (Cs NP) 输送系统,以增强Fasudil的角膜吸收.
- 评估Cs NP用于眼部药物输送的性能和生物相容性.
主要方法:
- 用于制备CsNP的离子凝方法.
- 统计实验设计优化了Cs NP特征.
- 进行了体外释放,体外透 (牛眼),HET-CAM,BCOP和细胞毒性试验.
主要成果:
- 通过结膜 (370.0 μg/cm2) 的法苏迪尔透率明显高于通过角膜 (96.8 μg/cm2).
- Cs NPs增强了Fasudil的角膜透,并提供了更慢的药物释放.
- 配制的CsNP表现出良好的眼部生物相容性和对镜片上皮细胞的低细胞毒性.
结论:
- 角膜对局部Fasudil化的吸收构成了障碍.
- 素纳米颗粒提供了一种可行的策略,以克服角膜障碍,以提高Fasudil的输送.
- 这项研究提供了第一份关于法苏迪尔化水的Cs NP介导眼睛吸收的报告.
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