通过Cinnamaldehyde与Streptococcus mutans作斗争,使用大自然
Zilefac Brian Ngokwe1,2, Amit Wolfoviz-Zilberman1, Esi Sharon1
1Department of Prosthodontics, Hadassah Medical Center, Faculty of Dental Medicine, Hebrew University of Jerusalem, Jerusalem 9112001, Israel.
Pharmaceutics
|January 23, 2024
概括
跨甲 (TC) 有效地对抗菌突变菌,这是导致牙的主要原因. 这种植物化学物质显示出强大的抗菌和抗菌膜作用,提供了一种有前途的天然策略来对抗牙损伤.
科学领域:
- 微生物学 微生物学
- 生物化学 生物化学
- 牙科研究 牙科研究
背景情况:
- 突变性链球菌 (Streptococcus mutans) 是主要的牙变质细菌,负责牙去矿化和牙变质的形成.
- 它的酸性和酸性特性对其毒性有很大贡献.
- 植物化学物质,如肉中的跨肉甲 (TC),以其广泛的抗菌活性而闻名.
研究的目的:
- 为了研究跨甲 (TC) 抗菌和抗菌膜的疗效,针对突变性链球菌.
- 为了确定TC对S. mutans的最小杀菌度 (MBC) 和亚MBC影响.
主要方法:
- 在体外评估TC对浮游生物S. mutans的抗菌活性.
- 使用微板光谱仪确定TC的最小杀菌度 (MBC).
- 通过使用盘共聚焦显微镜 (SDCM) 和高分辨率扫描电子显微镜 (HR-SEM) 分析的盘盘上TC的亚MBC剂量的抗菌膜效应的评估.
主要成果:
- 对浮游生物S. mutans的TC的最小杀菌度 (MBC) 确定为2500μg/mL.
- 甲基二硫氧化物 (DMSO) 溶剂对照没有表现出抗菌作用.
- 亚MBCTC剂量,特别是≥625μg/mL,显示出针对S. mutans.的显著抗菌膜活性.
结论:
- 跨甲 (TC) 具有强大的抗菌和抗菌膜特性,可对抗突变性菌株菌株.
- 625μg/mL的TC度被确定为这些活动中最有效的亚MBC剂量.
- TC 是一种有前途的天然化合物,可用于开发针对菌和牙的新策略.
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