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在现场形成基于PLGA的植入物中的突发释放:12个效应因子和纠正方法

Elena O Bakhrushina1, Polina S Sakharova1, Polina D Konogorova1

  • 1Department of Pharmaceutical Technology, A.P. Nelyubin Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119048, Russia.

Pharmaceutics
|January 23, 2024
PubMed
概括

了解现场植入物中的聚-DL-乳-co-glycolide (PLGA) 需要解决活性成分的"爆发释放". 本综述确定了影响突发释放的12个因素,并提出了控制其的策略,以改善药物输送.

关键词:
在 PLGA PLGA 中.爆发释放释放 爆发释放释放累积释放的累积释放量是多少在现场 (in situ) 进行.在现场形成植入物.一个相位逆转的相位逆转.

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