在多发性硬化症中个性化使用疾病修饰疗法
Chi-Yan Lee1,2, Koon-Ho Chan1,2,3
1Department of Medicine, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, 405B, 4/F, Professorial Block, 102 Pokfulam Road, Hong Kong.
Pharmaceutics
|January 23, 2024
概括
多发性硬化症 (MS) 治疗方法已经进步,提供个性化疾病修饰疗法 (DMT). 共享决策使患者能够根据个人需求和风险选择最佳的DMT.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 多发性硬化症 (MS) 是一种严重的神经系统疾病,影响全球数百万人,主要是年轻人.
- 在过去的二十年中,为MS治疗引入了十多种疾病修饰疗法 (DMT).
- 这些DMT在有效性,施用,副作用和怀孕方面的考虑方面各不相同.
研究的目的:
- 提供关于针对复发性多样性硬化症患者个性化DMT选择的最新审查.
- 强调在MS护理中个性化治疗策略的重要性.
- 倡导在DMT使用方面进行共享决策.
主要方法:
- 关于DMT治疗复发性多发性硬化症的当前文献的综述.
- 分析影响DMT选择的因素,包括患者异质性和治疗反应.
- 综合证据支持个性化医疗方法.
主要成果:
- 多发性硬化症患者在临床上具有多样性,疾病严重程度,MRI病变负载和DMT反应各不相同.
- 适当的DMT选择需要仔细考虑个体患者的个人资料和潜在的风险.
- 共享决策模式可以提高患者的参与度和治疗坚持度.
结论:
- 个性化DMT选择对于优化复发性MS的结果至关重要.
- 建议共享决策,纳入患者的偏好和风险/益处的理解.
- 根据个人多发性硬化症患者量身定制DMT可以提高治疗疗效和安全性.
相关概念视频
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
166
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
166
01:28Drug Therapy
45
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
45
01:29Inflammatory Bowel Disease IV: Pharmacological Management
127
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
127
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
01:22iPS Cell Differentiation
2.7K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.7K