通过实验设计,为眼部注射配制Resveratrol和 Melatonin自纳米乳化药物输送系统 (SNEDDS)
Elide Zingale1,2, Angela Bonaccorso1,2, Agata Grazia D'Amico3
1Laboratory of Drug Delivery Technology, Department of Drug and Health Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.
Pharmaceutics
|January 23, 2024
概括
自行纳米乳化药物递送系统 (SNEDDS) 提供了一种新的方式,可以将SIRT-1激活分子 (如白醇和黑激素) 输送到眼睛中. 这些系统提高了治疗退行性眼病的生物可用性,例如糖尿病视网膜病变.
科学领域:
- 眼部药物输送是通过眼部药物输送的.
- 纳米技术 纳米技术
- 药理学 药理学是指药理学的学科.
背景情况:
- 赛尔图因-1 (SIRT-1) 激活分子显示出对退行性眼病的治疗有前途.
- 这些分子的可溶性和生物利用性差,限制了这些分子的局部眼部输送.
- 需要创新的策略来增强眼部药物输送.
研究的目的:
- 设计和优化自纳米乳化药物输送系统 (SNEDDS),用于眼部输送白醇 (RSV) 和黑色素 (MEL).
- 评估SNEDDS对于糖尿病视网膜病变的潜在治疗.
- 评估SNEDDS用于眼睛的物理化学特性和细胞兼容性.
主要方法:
- 使用实验设计 (DoE) 和响应表面方法 (RSM) 制定SNEDDS.
- 使用各种表面活性剂 (Tween® 80,Tween® 20,Solutol® HS15,Cremophor® EL) 来优化SNEDDS.
- 对SNEDDS进行颗粒大小,PDI,乳液时间,药物含量,粘粘度,体外释放,pH,度和稳定性的表征;对SIRC细胞进行体外细胞相容性测试.
主要成果:
- 使用Tween® 80优化的SNEDDS表现出卓越的稳定性和有利的物理化学特性 (平均尺寸<50 nm,PDI<0.2,快速乳化时间).
- 观察到高药物含量 (>90%) 和持续的体外药物释放.
- 在子角膜上皮细胞 (SIRC) 上,SNEDDS 显示出良好的细胞相容性.
结论:
- SNEDDS是一种有前途的纳米载体系统,用于眼部输送白醇和黑激素.
- 这种方法可以克服治疗退行性眼病的传统交付的局限性.
- 进一步的研究可能会验证SNEDDS在糖尿病视网膜病变等疾病中的治疗应用.
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