在转移性结直肠癌中,与贝瓦齐祖马布相关的胃肠道穿孔
Kunpeng Fang1, Jie Wang2, Jianyong Yuan3
1Department of Special Treatment I, Third Affiliated Hospital of Naval Medical University (Eastern Hepatobiliary Surgery Hospital), Shanghai, China.
接受贝瓦齐祖马布治疗的转移性结直肠癌患者面临胃肠道穿孔的风险. 患者有肠道阻塞病史,年龄和性别可能是导致因素.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 贝瓦西祖马布是转移性结直肠癌的关键治疗方法.
- 胃肠道穿孔是与贝瓦西祖马布治疗相关的严重不良事件.
研究的目的:
- 在接受贝瓦西祖马布治疗的转移性结直肠癌患者中确定胃肠道穿孔的危险因素.
- 分析经历了胃肠道穿孔的患者的临床特征.
主要方法:
- 对217名接受贝瓦西祖马布治疗的转移性结直肠癌患者的回顾性审查.
- 对三个患有肠道穿孔症的患者的临床数据的分析.
主要成果:
- 在217名患者中,有3名患者 (1.4%) 在接受贝瓦西祖马布治疗后经历了肠道穿孔.
- 这三位患者都有肠道阻塞病史.
- 结果各不相同,两名患者最终死于穿孔,一名患者康复.
结论:
- 接受贝瓦齐祖马布治疗的晚期结直肠癌患者有胃肠道穿孔的风险.
- 患者年龄,性别和肠道阻塞史等因素可能与这种不良事件有关.
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