肥胖对脏疾病的影响:观察性队列研究分析了14492例脏活检病例
Tae-Bum Kim1, Shin Young Ahn2, Jieun Oh3
1Department of Internal Medicine, Goesan Sungmo Hospital, Goesan, Korea.
Journal of Korean medical science
|January 23, 2024
概括
肥胖增加了焦点细分型血小板硬化 (FSGS) 和高血压脏病 (HT-N) 的风险,并在IgA脏病 (IgAN) 和狼性炎 (LN) 患者中增加了末期脏病 (ESKD) 的风险. 仅仅与肥胖相关的淋巴细胞病变 (ORG) 可能有更好的结果.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 肥胖医学 肥胖医学
- 流行病学 流行病学
背景情况:
- 全球肥胖流行病与新出现的脏疾病有关,例如与肥胖相关的结质病 (ORG).
- 肥胖对活检证明的脏疾病的患病率和结果的影响仍未得到充分研究.
- 了解这些关联对于管理日益肥胖的人群中的脏健康至关重要.
研究的目的:
- 调查肥胖与各种脏疾病的患病率和结果之间的联系.
- 为了确定特定的病风险和与肥胖相关的进展.
- 分析肥胖个体中与肥胖相关的球瘤病变 (ORG) 的结局.
主要方法:
- 从18家韩国医院 (1979-2018) 分析了14492次脏活检.
- 肥胖症定义为身体质量指数 (BMI) ≥30 kg/m2.
- 统计分析包括几率比率 (OR) 和相对风险 (RR) 以95%的置信区间 (CI).
主要成果:
- 在肥胖和非肥胖群体中,IgA病 (IgAN) 是最常见的疾病.
- 肥胖与焦点细分型淋巴结核硬化 (FSGS) 和高血压脏病 (HT-N) 的风险增加有关.
- 在Igan和狼性炎 (LN) 患者中,肥胖增加了末期病 (ESKD) 的风险,而ORG患者在与其他病同时发生时,ESKD风险更高.
结论:
- 肥胖与FSGS和HT-N的发病率较高有关.
- 肥胖会加剧患有Igan和LN的患者的ESKD风险.
- 在没有其他脏疾病的情况下,与肥胖相关的淋巴结核病 (ORG) 可能具有有利的脏结果.
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