在患有内高血压的患者中,光学连贯性断层扫描血管图分析
Lidia Remolí-Sargues1, Clara Monferrer-Adsuara1, Belén López-Salvador1
1Department of Ophthalmology, Consorcio Hospital General Universitario of Valencia, Av. Tres Cruces 2, 46014, Valencia, Spain.
European journal of ophthalmology
|January 23, 2024
概括
周周细胞微血管密度与质细胞内形层厚度在内高血压 (IIH) 中有关. 在IIH患者中降低GCIPL厚度和周包膜 perfusion 密度表明潜在的早期视神经缩指标.
科学领域:
- 眼科医生 眼科 眼科
- 神经科学是一个神经科学.
- 医疗成像医学成像
背景情况:
- 内高血压 (IIH) 可以导致皮囊,可能导致视神经受损.
- 有限的证据表明,在IIH中的 papilledema 回归后,周周细胞微血管的变化存在.
- 了解这些微血管变化可能会为IIH患者的视神经健康提供见解.
研究的目的:
- 在IIH患者中调查视网膜和视神经结构性变化与周周细胞微血管学之间的关联.
- 为了将IIH患者的微血管和结构参数与回归的乳头瘤对照对象进行比较.
主要方法:
- 对21名IIH患者的39只眼睛进行了回顾性研究.
- 光学连贯断层扫描 (OCT) 检测视网膜神经纤维层 (RNFL) 和质细胞内状层 (GCIPL) 厚度.
- 光学一致性断层扫描血管图 (OCTA) 检测周周毛囊 perfusion 密度 (PD) 和流量指数 (FI).
主要成果:
- 在GCIPL厚度和周囊PD和FI之间发现了很高的相关性 (p<0.05,r>0.7).
- 观察到RNFL厚度和周周细胞微血管参数之间的相关性很低.
- 与对照组相比,IIH患者的回归型 papilledema 显示显著降低 GCIPL 厚度和周边 papillary PD (p<0.05).
结论:
- 周周细胞微血管参数,特别是PD,与IIH中的GCIPL厚度有很强的相关性.
- 在IIH患者中,降低GCIPL厚度和周周巴皮lary PD,表明潜在的结构损伤.
- 周周细胞微血管测量可以作为IIH视神经缩的早期指标.
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