[手术和泌尿器官学中的脏应急综合征:概念,发病,预防和纠正的基础]
A P Vlasov1, V A Trofimov1, T I Vlasova1
1National Research Mordovian State University named after N.P. Ogarev, Saransk, Russia.
Khirurgiia
|January 23, 2024
概括
这项研究在紧急的手术和泌尿神经病例中发现了一种新的疾病 - - 性应急综合征. 雷马克索尔有效地改善功能,并通过减少氧化应激和脂酶活性来纠正这种综合征.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 手术病理学手术病理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 紧急的手术和泌尿神经病症通常会导致严重的损伤.
- 脏变化的发展及其对恒温的影响尚未完全理解.
- 在这些关键情况下,现有的疗法可能无法充分解决损伤的潜在机制.
研究的目的:
- 在紧急的手术和尿病理中识别和描述变化的一般模式.
- 为了研究这些脏变化的作用在恒常性障碍的发病过程中.
- 为了确定雷马在纠正新提出的疾病中的有效性:性应急综合征.
主要方法:
- 实验性研究在狗中诱导腹膜炎,胰腺炎和肠道阻塞.
- 评估功能,排毒,脂质过氧化和脂酶活性.
- 临床研究中,患者患有急性腹膜炎,胰腺炎,肠道阻塞和炎炎,有或没有Remaxol治疗.
主要成果:
- 在各种急性疾病中,在实验和临床环境中观察到功能显著下降.
- 急性损伤与组织的膜稳定相关,严重程度与疾病进展有关.
- 雷马克索尔的使用改善了对病原性因素的耐受性,并提高了整体功能状态.
结论:
- 实验和临床数据支持一种新的症状综合体的概念:在外科手术和泌尿腎病学中的性应急综合征.
- 性应急综合征的特征是由于功能受损导致的逐渐内源性中毒.
- 这种损伤是由于氧化应激和脂酶活性驱动的细胞膜稳定导致的,而雷马可以减轻这种影响.
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