相关实验视频

Updated: Jul 5, 2025

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

基于小组的轨迹建模,以确定儿童和青少年与抗精神病药物相关的体重增加模式

Ning Lyu¹, Susan Abughosh¹, Tyler J Varisco¹

¹Department of Pharmaceutical Health Outcomes and Policy, College of Pharmacy, University of Houston.

Journal of clinical psychopharmacology

|January 23, 2024

概括

与抗精神病药物相关的体重增加 (AAWG) 影响了第二代抗精神病药物 (SGA) 的儿科患者的四分之一. 风险因素,如年轻的年龄和特定的初始SGA预测持续的体重增加轨迹.

科学领域:

儿科药理学儿科药理学
临床精神病学是一门临床精神病学专业.
药物不良反应药物不良反应

背景情况:

与抗精神病药物相关的体重增加 (AAWG) 是使用第二代抗精神病药物 (SGA) 的儿科患者的一个重大问题.
识别明显的体重增加模式和相关的风险因素对于管理这种不利影响至关重要.

研究的目的:

为了确定AAWG在儿童和青少年治疗SGA的潜伏轨迹.
检查与这些已识别的AAWG轨迹相关的风险因素.

主要方法:

对IQVIA门诊EMR-US数据库 (2016-2021) 的回顾性分析.
包括6-19岁的SGA-naive患者,连续使用SGA处方至少90天.
应用基于组的轨迹建模对AAWG超过24个月和多项式后勤回归用于风险因素分析.

主要成果:

确定了四种AAWG轨迹:持续的严重体重增加 (4.2%),持续的中度体重增加 (20.1%),轻微的体重变化 (69.6%) 和逐渐的体重减轻 (6.1%).
年轻的年龄,较低的基线BMIz-score和初始 olanzapine 处方与严重的体重增加有关.
预测模型表现出强大的歧视力 (AUC为0.91和0.8).

结论:

大约25%的儿科SGA接受者经历了持续的体重增加.
患者的特征和最初的SGA选择可以预测持续AAWG的风险,从而实现个性化风险评估.

更多相关视频

Self-Administration of Drugs in Mouse Models of Feeding and Obesity

Self-Administration of Drugs in Mouse Models of Feeding and Obesity

Published on: June 8, 2021

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa

Published on: October 22, 2015

相关概念视频

Modeling in Therapy

Modeling in Therapy

Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...

Antidepressant Drugs: MAOIs and Other Agents

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...

Regression Toward the Mean

Regression Toward the Mean

Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...