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在P-糖蛋白中追踪基质转位机制

Theresa Gewering1,2, Deepali Waghray3, Kristian Parey1,2,4

  • 1Osnabrück University, Department of Biology/Chemistry, Structural Biology Section, Osnabrück, Germany.

eLife
|January 23, 2024
PubMed
概括

使用cryoEM可视化P-glycoprotein (Pgp) 药物运输,揭示了一种新的机制,即超膜螺旋1调节基质通道. 这一发现挑战了现有的流量模型,并确定了新的药物点.

关键词:
在ABC运输器上,ABC运输器这是一种P-glycoprotein蛋白.生物化学 生物化学化学生物学 化学生物学一个共价连接体.化-EM结构的结构.这是一个机制机制.分子生物物理学分子生物物理学这里是鼠标鼠标鼠标鼠标鼠标鼠标.面向外的形状是面向外的形状.结构生物学结构生物学基板转位的转位

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