抗抑郁药塞特拉林在APPswe/PSEN1dE9转基因小鼠中增加了 thioflavin-S 和刚果红的沉积
Ming-Hsuan Liao1, Yen-Kuang Lin2, Fong-Ying Gau3
1Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Frontiers in pharmacology
|January 23, 2024
概括
这项研究发现,常见的抗抑郁药Sertraline和Paroxetine可能会加剧阿尔茨海默氏症 (AD) 病理. 塞特拉林在小鼠模型中增加了粉样蛋白斑块和认知缺陷,这表明需要重新评估它们在阿兹海默症患者中的使用.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 病理学 病理学 病理学
背景情况:
- 抑郁症经常与阿尔茨海默病 (AD) 相伴.
- 抗抑郁药在阿尔茨海默病患者中很常见,但它们对阿尔茨海默病发病的影响尚不清楚.
研究的目的:
- 调查塞特拉林和帕罗克塞丁对老鼠模型中AD病理和认知功能的影响.
主要方法:
- 给野生类型和APPswe/PSEN1dE9 (APP/PSEN1) 转基因小鼠服用12个月的塞特拉林或帕洛克塞丁.
- 量化药物度,测量血清血清激素,并评估粉样蛋白负担和识别记忆.
主要成果:
- 帕洛西丁增加了APP/PSEN1小鼠的体重增加和死亡率.
- 塞特拉林在APP/PSEN1小鼠的海马体和同皮质中显著增加了粉样蛋白和化标志物.
- 这两种抗抑郁药在APP/PSEN1小鼠中的识别记忆受损.
结论:
- 塞特拉林可能在阿尔茨海默病的发病过程中发挥作用.
- 在阿尔茨海默病患者中使用塞特拉林和帕洛克塞丁需要仔细重新评估.
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