抗生素暴露与精神疾病风险降低有关
Ilan A Kerman1,2, Matthew E Glover2, Yezhe Lin3,4,5
1Mental Health Integrated Care Community, Minneapolis Veterans Administration Health Care System, Minneapolis, MN, United States.
Frontiers in pharmacology
|January 23, 2024
概括
在住院期间使用抗生素可能会降低患情绪和焦虑障碍的风险. 这种保护作用因年龄和性别而异,在某些群体中观察到有意伤害和自杀倾向的显著减少.
科学领域:
- 精神病学是一个精神病学.
- 微生物学 微生物学
- 流行病学 流行病学
背景情况:
- 肠道微生物组在心理健康中起着至关重要的作用.
- 抗生素诱导的微生物组变化可能会影响精神疾病风险.
- 了解这些关联对于公共健康至关重要.
研究的目的:
- 调查住院患者抗生素暴露与随后精神疾病风险之间的关联.
- 探索抗生素使用对心理健康结果的特定年龄和性别影响.
主要方法:
- 这是一项回顾性队列研究,利用国家医疗保健数据库对6900万患者的数据.
- 确定了20,214名在住院期间接触过抗生素的成年患者,并将他们与41,555名未接触过的对照进行了匹配.
- 对人口统计,影响微生物群的变量,心理健康和整体健康状况进行控制.
主要成果:
- 抗生素暴露与新情绪障碍和各种年龄和性别层面的焦虑/压力相关障碍的风险降低有关.
- 在男性和老年人 (≥50岁) 中观察到有意伤害和自杀倾向的显著风险降低.
- 在50岁及以上的个体中,发现精神疾病风险降低.
结论:
- 住院抗生素使用显示出对多种精神病的保护性关联.
- 观察到的保护作用取决于患者的年龄和性别.
- 需要进一步的研究来阐明这些发现背后的机制.
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