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阴道微生物群中的乳酸菌减少与高风险HPV感染妇女的HPV持续性独立相关
Elif Avsaroglu1, Babur Kaleli2, Derya Kilic2
1Obstetrics and Gynecology, Denizli State Hospital, Denizli, TUR.
Cureus
|January 23, 2024
概括
阴道微生物群中乳酸菌的减少与持续高风险的人类乳头瘤病毒 (HPV) 感染有关. 这种不平衡可能会导致HPV的持续性,无论年龄和更年期状态如何.
科学领域:
- 妇科 妇科医生 妇科
- 微生物学 微生物学
- 传染性疾病 传染性疾病
背景情况:
- 阴道失调,微生物物种的不平衡,可以触发局部免疫和代谢变化导致慢性炎症.
- 人类乳头瘤病毒 (HPV) 感染的清除或进展背后的机制尚不清楚.
- 这项研究调查了阴道失生症在宫HPV感染的持续性方面的潜在作用.
研究的目的:
- 确定乳杆菌主导指数与宫高风险HPV (HR-HPV) 持续存在之间的关联.
- 探索阴道微生物群组成和HPV感染结果之间的联系.
主要方法:
- 对100名患有高风险HPV感染的妇女进行了随访.
- 参与者被分为HPV阳性 (持久性) 和HPV阴性 (清除) 组.
- 宫和阴道和血液样本被分析到Nugent得分,乳酸菌优势和白细胞计数.
主要成果:
- 在43%的患者中观察到HPV持续性.
- 统一分析表明,年龄,更年期状态和乳酸菌减少与HPV持久性有关.
- 后勤回归证实,减少乳酸菌独立预测HPV持久性 (OR:2.668,p<0.05),无论年龄和更年期.
结论:
- 宫性阴道微生物群中的乳酸菌减少与HPV的持续性有显著的关联.
- 这种关联无论患者的年龄和更年期状况如何,都是如此.
- 研究结果表明,保持健康的乳酸菌占主导地位的阴道微生物组可能对HPV清除至关重要.
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