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Updated: Jul 5, 2025

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol
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Published on: December 30, 2016

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在对IL-12治疗的反应中,PRMT5调节了抑制Th1类iTregs的表观遗传变化

Nidhi Jadon1, Sudarvili Shanthalingam2, Gregory N Tew3

  • 1Graduate Program in Animal Biotechnology and Biomedical Sciences, Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA, United States.

Frontiers in immunology
|January 23, 2024
PubMed
概括

治疗性T辅助1样诱导调节性T细胞 (iTregs) 显示增强的抑制功能. 蛋白质氨酸甲基转移酶5 (PRMT5) 调节这些细胞,为无形性贫血 (AA) 治疗提供了潜力.

关键词:
类似于T型辅助T型的诱导调节性T细胞 (Th1-like iTregs)无塑性贫血 (AA) 是一种疾病.骨髓功能衰竭 (BMF) 是指骨髓功能衰竭.介质蛋白-12 (IL-12) 是一种后翻译修改 (PTMs) 是指翻译后的修改.蛋白质氨酸甲基转移酶5 (PRMT5) 是一种蛋白质1 (SIRT1) 的第1种蛋白质对称的组织素二甲基化 (H3R2me2s)

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