血小板在脑病理期间在血脑屏障中的作用
Weifeng Lv1, Xiaofan Jiang1, Yanyu Zhang1
1Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Frontiers in cellular neuroscience
|January 23, 2024
概括
血小板在血脑屏障 (BBB) 中具有双重作用. 虽然传统上被视为保护性,但新的证据表明血小板也可以通过各种释放的因素和相互作用损害BBB.
科学领域:
- 神经科学是一个神经科学.
- 血液学 血液学 血液学
- 血管生物学 血管生物学
背景情况:
- 血小板对于静血和维持血脑屏障 (BBB) 完整性至关重要.
- BBB保护神经组织,但在脑炎症,瘤,创伤或出血时,其平衡受到挑战.
- 传统上,人们认为血小板通过形成血栓来保护BBB,但最近的证据表明,它们也可能造成损伤.
研究的目的:
- 审查最近关于血小板在BBB完整性中的双重作用的文献.
- 专注于血小板调解BBB损伤的机制.
- 探索血小板释放因素如何影响BBB透性和神经炎症.
主要方法:
- 对最近发表的文章进行系统审查.
- 对调查血小板与BBB相互作用的研究进行分析.
- 检查背后的分子机制血小板介导的BBB效应.
主要成果:
- 血小板释放的因素包括血小板激活因子 (PAF),P-选择素,ADP和PDGF超级家族蛋白质 (例如PDGF-AA,PDGF-CC),这些蛋白质增加了BBB的透性.
- 血小板分泌的胺β (Aβ) 促进神经炎症,并降低紧密结合分子 (例如,克劳丁-5) 的调节,损害BBB.
- 血小板-中性粒细胞聚合物释放活性氧物种 (ROS),损害内皮细胞,而一些因素,如PDGF-BB提供保护.
结论:
- 血小板在BBB完整性中表现出双重作用,能够同时保护和损害.
- 血小板衍生因素和相互作用显著影响BBB透性和神经炎症.
- 了解这些复杂的机制对于解决涉及BBB功能障碍的神经障碍至关重要.
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