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内和外动脉样硬化与白质强度过高之间的关联:系统性审查和元分析

Wenyuan Zhang¹, Fangwang Fu², Zhenxiang Zhan³

¹Department of Neurology, Affiliated Yueqing Hospital, Wenzhou Medical University, Yueqing, China.

Frontiers in aging neuroscience

|January 23, 2024

概括

动脉硬性狭窄,无论是内还是外,都与白质超强度 (WMHs) 有关. 额外缩症显示出显著的关联,而缩症与WMHs的联系不那么明显.

科学领域:

神经成像是一种神经成像.
脑血管疾病脑血管疾病
血管神经学血管神经学

背景情况:

白质超强度 (WMHs) 是大脑小血管疾病的关键神经成像指标.
大脑小血管疾病与显著的神经缺陷有关.

研究的目的:

调查内和外动脉缩狭窄症和WMHs之间的关联.
确定动脉样硬化狭窄是否有助于WMHs的发展.

主要方法:

在PubMed,Web of Science和Embase的系统文献搜索到2023年3月.
包括检查动脉样狭窄症和WMHs之间的联系的横截面研究.
使用随机效应模型汇集估计的元分析.

主要成果:

21项研究 (10,841名参与者) 显示,动脉样硬化狭窄与WMH风险和体积增加有关.
脑外动脉硬性狭窄症 (ECAS) 与WMH显著相关 (OR 2.10).
内动脉样硬化狭窄症 (ICAS) 与WMHs的相关性是微不足道的 (OR 1.75),并注意到异质性.

结论:

内和外动脉样硬化狭窄症与WMHs有关.
这种关联对于ECAS来说是显著的,但对于ICAS来说是减弱的.
这些发现突显了动脉样硬化在白质损伤中的作用.

关键词:

大脑小血管疾病是大脑小血管疾病.脑外动脉样硬化症脑外动脉样硬化内动脉样硬化内动脉样硬化这是一个元分析.白质的超强度是白质的超强度.

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