三种形式的局部皮质类固醇对鼻多重症的影响
Matin Ghazizadeh1, Ali Goljanian Tabrizi1, Najmeh Rajabi1
1Department of Otorhinolaryngology, Head and Neck Surgery, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iranian journal of otorhinolaryngology
|January 23, 2024
概括
布德索尼德雾化悬浮有效地预防手术后鼻腔多重症的复发,优于贝塔梅他鼻液. 这种局部皮质类固醇为接受功能性内镜外科手术的患者提供了更好的结果.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 鼻科 鼻科是指鼻科的专家.
- 药理学 药理学是指药理学的学科.
背景情况:
- 鼻多重症 (SNP) 经常在手术后复发,需要有效的预防性治疗.
- 局部皮质类固醇正在探索其降低SNP复发率的潜力.
- 对比不同的皮质类固醇配方对于优化术后护理至关重要.
研究的目的:
- 为了比较三种局部皮质类固醇形式在功能性内镜性鼻手术 (FESS) 后预防鼻多重症复发的疗效.
主要方法:
- 一个双盲,随机的临床试验,涉及108名SNP患者接受FESS.
- 患者被随机分为三个组:布德索尼德喷雾剂,贝塔美沙滴剂和布德索尼德雾化悬浮剂.
- 术后一个月和六个月通过鼻腔内镜评估复发情况; SNOT 22问卷评估了主观改善.
主要成果:
- 与贝塔梅他鼻液相比,布德塞诺雾化悬浮在预防SNP复发方面表现出更高的疗效 (P=0.043).
- 在布德索尼德雾化悬浮剂和布德索尼德喷雾剂 (P=0.178) 之间,在预防复发方面没有发现显著差异.
- 接受布塞索尼德雾化悬浮的患者报告了面部丰满度的显著改善.
结论:
- 布德索尼德雾化悬浮剂在预防FESS后鼻多样性复发方面比贝塔梅他鼻滴更有效.
- 局部皮质类固醇治疗,特别是布德胺雾化悬浮剂,在治疗复发性SNP方面发挥着关键作用.
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