年轻成年人的肺功能与中度到晚期早产有关
Björn Lundberg1,2, Simon Kebede Merid1, Petra Um-Bergström1,2
1Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
ERJ open research
|January 23, 2024
概括
中度到晚期的早产与24岁男性的下肺功能 (FEV1) 有关. 雌性在年轻成年时显示肺功能赶上,已识别出明显的早产期肺功能表型.
科学领域:
- 肺部医学 肺部医学
- 儿科肺病学 儿科肺病学
- 发展生物学 发展生物学
背景情况:
- 中期到晚期的早产 (32至<37周妊娠期) 与青少年肺功能缺陷有关.
- 关于成年人的肺功能和这个人群中详细的生理表型的数据有限.
- 研究长期肺功能轨迹对于了解健康结果至关重要.
研究的目的:
- 检查从青春期到年轻成年期的中晚期早产个体的肺功能发展.
- 为了提供超越螺旋计的综合生理表型.
- 为了确定中晚早产的年轻成年人独特的肺功能模式.
主要方法:
- 从16岁和24岁的BAMSE队列中分析肺功能数据 (呼吸计,FENO,MBNW).
- 包括中期到晚期早产 (n=110) 和满期 (n=1895) 出生的个体.
- 调整为性别和吸烟的回归模型;用于表型化的隐性类别分析.
主要成果:
- 在24岁时,中期到晚期早产的男性在1秒内出现较低的强迫呼气体积 (FEV1).
- 女性在16至24岁之间表现出显著的FEV1追赶.
- 确定的肺功能表型:"喘样","dysanapsis样"和"预产参考";与"喘样"表型相关的孕产妇超重.
结论:
- 在中期到晚期早产的男性中,肺功能峰值受损 (FEV1).
- 中期到晚期早产的女性在年轻成年时经历了肺功能追赶.
- 在中期到晚期早产的个体中存在各种肺功能障碍表型.
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