长期暴露在蓝色发光二极管中,会导致与胆固醇失调相关的肠道失调
Cheng-Hsieh Huang1,2, Sebastian Yu3, Hsu-Sheng Yu4
1Ph. D. Program in Environmental and Occupational Medicine, College of Medicine, Kaohsiung Medical University and National Health Research Institutes, Kaohsiung, Taiwan.
Frontiers in cellular and infection microbiology
|January 23, 2024
概括
长期暴露在夜间蓝色发光二极管 (LED) 照明中会破坏肠道微生物群和胆固醇代谢. 高强度的蓝色LED灯对肠道细菌多样性产生负面影响,并增加有害细菌,特别是影响总胆固醇 (TCHO) 水平.
科学领域:
- 微生物学 微生物学
- 代谢科学 代谢科学
- 时间生物学 时间生物学
背景情况:
- 夜班工作与昼夜节律扰乱和代谢障碍有关.
- 肠道微生物群在代谢健康中起着至关重要的作用.
- 发光二极管 (LED) 照明对肠道微生物群和脂质的慢性影响尚未完全理解.
研究的目的:
- 研究夜间蓝色和白色LED照明对小鼠肠道微生物群和血清脂质的慢性影响.
- 了解LED光的不同辐射和颜色如何影响微生物多样性,丰富性和宿主脂质代谢.
主要方法:
- 雄性C57BL/6小鼠在特定的夜间Zeitgeber时间暴露在蓝色或白色LED光线下,持续33周.
- 分析了肠道微生物群的α多样性和血清脂质概况 (总胆固醇和甘油三).
- 评估了微生物的丰富性和有益细菌与有害细菌的比例.
主要成果:
- 高辐射蓝色LED光显著减少了肠道微生物群的α多样性.
- 蓝色和白色LED光线的低辐射增加了血清总胆固醇 (TCHO),但不是甘油三 (TG).
- 有益细菌与有害细菌的比率在低辐射蓝光下降,但在高辐射蓝光下增加,与TCHO负相关.
结论:
- 慢性高辐射蓝色LED照明可以诱导肠道失调,其特点是微生物多样性减少和细菌比例改变,导致小鼠的胆固醇代谢失调.
- 夜班工作者应避免长时间暴露在蓝色LED照明中,以减轻对肠道微生物群和脂质资料的潜在负面健康影响.
相关概念视频
01:17Chronic Bowel Disorders: Introduction
450
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
450
01:24Chronic Pancreatitis I: Introduction
89
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
89
01:17Irritable Bowel Syndrome I: Introduction
276
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
276
01:18Lipids: Dietary Sources and Requirements
741
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
741
01:29Cholesterol: Significance and Regulation
548
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
548