治疗儿童功能性便秘的益生菌:重叠系统性审查的概述
Yunxin Zhang1, Aiping Li2, Jing Qiu3
1Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Frontiers in cellular and infection microbiology
|January 23, 2024
概括
益生菌可能有助于儿童功能性便秘 (FC),但目前的证据质量较低. 需要更严格的系统审查 (SRs) 和元分析 (MAs) 才能获得明确的结果.
科学领域:
- 儿科 儿科 儿科
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
背景情况:
- 功能性便秘 (FC) 是一个常见的儿科胃肠道问题.
- 益生菌越来越多地被探索为儿童FC的治疗选择.
- 对儿科FC益生菌的现有证据综合需要进行批判性评估.
研究的目的:
- 系统地整理,评估和综合从系统审查 (SRs) 和元分析 (MAs) 关于儿科FC的益生菌疗效的证据.
- 评估现有SRs/MAs的方法论,报告和证据质量.
- 识别差距,并为未来的研究方向提供信息.
主要方法:
- 通过主要数据库 (Cochrane Library,PubMed,Embase,Web of Science) 系统地识别儿童中FC的益生菌的SRs/MAs.
- 使用多次系统审查评估2 (AMSTAR-2) 方法质量的独立评估.
- 使用系统审查和元分析 (PRISMA) 的首选报告项目评估报告质量,使用推,评估,开发和评估 (GRADE) 的评级评估证据质量.
主要成果:
- 七个SR/MA符合纳入标准.
- 包括的SRs/MAs表现出非常低的方法质量 (AMSTAR-2) 和不满意的报告质量 (PRISMA).
- 益生菌疗效的证据质量从非常低到中度 (GRADE) 之间.
结论:
- 益生菌对改善儿童功能性便秘有潜在的益处.
- 显著的局限性和不一致的发现需要进一步提供高质量的SR/MA.
- 对于关于在儿科FC中使用益生菌的最终结论,需要有坚实的证据.
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