相关实验视频

Updated: Jul 5, 2025

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

与单独使用药物治疗相比,深度大脑刺激对帕金森病进展的影响

Wenwen Dong¹, Chang Qiu¹, Yue Lu¹

¹Department of Functional Neurosurgery, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.

Frontiers in neuroscience

|January 23, 2024

概括

对帕金森病 (PD) 进行深度大脑刺激 (DBS) 可能会略有加快运动进展,但与单独药物治疗相比,可以显著改善生活质量并减少护理人员的负担.

科学领域:

神经学神经学
神经外科神经外科

背景情况:

帕金森病 (PD) 是一种进展性神经退行性疾病,其特征是运动症状恶化.
深度大脑刺激 (DBS) 是PD的侵入性治疗选择,但其对疾病进展的影响尚不清楚.

研究的目的:

为了比较DBS与药物治疗对帕金森病在两年时间内的进展的影响.

主要方法:

一组77名PD患者 (Hoehn和Yahr阶段2.5-3) 被分为药物治疗 (n=34) 和DBS (n=43) 组.
评估包括统一帕金森病评分表第三部分 (UPDRS-III),蒙特利尔认知评估 (MOCA),焦虑,抑郁,生活质量 (PDQ-39),以及2年的护理人员负担 (ZCBS).
此外,还监测了莱沃多巴等效剂量 (LED) 和治疗成本.

主要成果:

虽然UPDRS-III分数在两组都增加了,但在DBS组的增加更大.
在药物治疗组中,认知能力下降 (MOCA) 更明显.
DBS改善了生活质量 (PDQ-39),减少了药物需求 (LED) 和减少了护理人员负担 (ZCBS).

结论:

帕金森病无论治疗如何都会进展,在DBS组的运动进展可能稍快一些.
DBS在改善运动功能,改善生活质量和减少家庭负担方面提供了显著的好处.
与单独使用药物治疗相比,DBS对认知和心理健康产生了更有利的影响.

关键词:

帕金森病是帕金森氏症的一种疾病.在 UPDRS-III 中,深度大脑刺激 - - 深度大脑刺激疾病的进展疾病的进展后续行动后续行动

更多相关视频

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

Published on: May 31, 2016

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

相关概念视频

Parkinson's Disease: Treatment

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...

Parkinson's Disease: Overview

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...

Alzheimer's Disease: Treatment

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...