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天然干燥甲状腺用于治疗甲状腺功能低下症?
Adrian H Heald1,2, Peter Taylor3, Lakdasa Premawardhana3
1The School of Medicine and Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom.
Frontiers in endocrinology
|January 23, 2024
概括
自然干燥甲状腺 (NDT) 可能有利于甲状腺功能低下症患者对levothyroxine无反应. 新出现的证据表明,在NDT中甲氨酸可以减轻当其他诊断被排除在外时,持续的症状.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 甲状腺学 甲状腺学
背景情况:
- 初级甲状腺功能低下症影响大约3%的欧洲人口.
- 从历史上看,自然干燥甲状腺 (NDT) 是标准的治疗方法,直到20世纪70年代.
- 莱沃甲状腺素 (L-甲状腺素) 现在是治疗甲状腺功能低下的主要治疗方法.
研究的目的:
- 为了探索liothyronine的潜在疗效,一个NDT的组成部分,在levothyroxine不响应的甲状腺功能低下患者.
- 在排除其他疾病后,评估支持症状个体的NDT的证据.
主要方法:
- 对甲状腺功能低下症的历史治疗实践的审查.
- 对新出现的证据分析Liothyronine和NDT的疗效.
- 考虑差异性诊断和替代治疗选择.
主要成果:
- 在NDT中含有levothyroxine和liothyronine两种药物.
- 一部分甲状腺功能低下患者尽管接受了levothyroxine治疗,但仍然表现出症状.
- 事证据表明,在精心挑选的病例中,NDT可以缓解症状.
结论:
- 甲胺在NDT中的作用可能解释其在一些耐火性甲状腺功能低下病例中的有效性.
- 对于某些患有持续性甲状腺功能低下症状的患者来说,NDT可能是有益的选择.
- 仔细的患者选择和排除其他诊断对于考虑NDT至关重要.
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