在肥胖症中,稳态和氧化还原变化
Cristina Franco1, Lorella Maria Teresa Canzoniero1
1Department of Science and Technology, University of Sannio, Benevento, Italy.
Frontiers in endocrinology
|January 23, 2024
概括
细胞和氧化还原平衡与肥胖等慢性疾病有关. 本综述探讨了载体如何影响这种关系,并导致与肥胖相关的氧化还原应激.
科学领域:
- 生物化学 生物化学
- 细胞生物学 细胞生物学
- 生理学 生理学 生理学
背景情况:
- 在慢性疾病,特别是肥胖症中,细胞和氧化还原平衡受损.
- 氧化还原代谢和离子之间存在复杂的相互作用,影响细胞功能.
- 状态的干扰显著影响系统和细胞的氧化还原平衡.
研究的目的:
- 审查和氧化还原平衡在健康和疾病中的相互相互作用.
- 突出在与肥胖相关的氧化还原应激改变中的作用.
- 检查载体在维持平衡中的作用及其与肥胖的联系.
主要方法:
- 文献综述总结当前的知识.
- 分析和氧化还原代谢之间的双向关系.
- 专注于转运体 (ZnT和ZIP家族) 在平衡中的作用.
主要成果:
- 氧化还原代谢会影响的稳态和细胞中的可用性.
- 具有亲抗氧化特性,可以调节氧化还原代谢.
- 载体的改变表达和活性与肥胖和氧化还原应激有关.
结论:
- 在生理和病理生理状态中,和氧化还原平衡之间的复杂关系至关重要.
- 转运体在调节平衡中起着关键作用,对与肥胖相关的氧化还原应激有影响.
- 了解这种相互作用为潜在的肥胖治疗策略提供了见解.
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