莱沃甲状腺素个性化治疗:这是一个梦想吗?
Carlo Cappelli1, Elisa Gatta1, Salvatore Ippolito2
1Department of Clinical and Experimental Sciences, SSD Endocrinologia, University of Brescia, ASST Spedali Civili of Brescia, Brescia, Italy.
Frontiers in endocrinology
|January 23, 2024
概括
甲状腺功能低下症的Levothyroxine疗法已取得显著进展,但许多患者仍然未得到充分治疗. 未来的策略可能涉及数字疗法,以实现个性化剂量和改善结果.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 数字健康数字健康
背景情况:
- 利沃甲状腺素是对甲状腺功能低下症的关键治疗方法,其历史配方从甲状腺提取物演变为针对吸收不良的先进配方.
- 尽管取得了进展,但仍有相当数量的患者经历了低于最佳的勒沃西治疗,这表明在实现最佳治疗结果方面存在持续的挑战.
研究的目的:
- 审查莱沃西素配方和甲状腺功能低下症治疗策略的历史演变.
- 确定阻碍实现针对个体患者量身定制的勒沃西治疗的关键因素.
- 探索数字疗法在优化levothyroxine治疗和实现个性化医疗方面的潜力.
主要方法:
- 关于Levothyroxine治疗进展的历史审查.
- 对Levothyroxine治疗和患者管理当前挑战的分析.
- 探索数字疗法和未来在甲状腺功能低下症治疗中的技术整合.
主要成果:
- 莱沃甲状腺素治疗已经从原始甲状腺提取物发展到复杂的配方,旨在克服吸收问题.
- 低于最佳治疗率仍然很高,这凸显了当前指南和个性化患者护理之间的差距.
- 数字疗法为提高治疗效率和实现个性化的勒沃西剂量提供了一个有希望的途径.
结论:
- 尽管有历史上的进步,但由于各种因素,实现量身定制的勒沃西治疗仍然是一个挑战.
- 数字疗法的整合具有显著的潜力,可以改善低甲状腺症管理中的患者结果.
- 未来的研究应该专注于利用技术来开发个性化的Levothyroxine治疗策略.
相关概念视频
01:20Synthesis and Regulation of Thyroid Hormones
4.6K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.6K
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
01:23The Thyroid Gland
3.9K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
3.9K
01:20Myasthenia Gravis: Overview and Treatment
1.4K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.4K
01:18Functions of Thyroid Hormones
2.8K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.8K
01:28Drug Therapy
44
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
44