通过获得自我调节的超基因进化
Nicholas W VanKuren1, Sofia I Sheikh1, Claire L Fu1
1Department of Ecology & Evolution, The University of Chicago, Chicago IL USA.
bioRxiv : the preprint server for biology
|January 23, 2024
概括
研究人员发现了新的调节元件,可以控制尾蝶的双性基因. 这一发现解释了超基因是如何进化和选择基因的新功能,支持经典的超基因理论.
科学领域:
- 进化发育生物学 进化发育生物学
- 遗传学 遗传学 是一个
- 昆虫学 昆虫学是一门学科.
背景情况:
- 种类进化出多种表型,通常由超基因联的发育调节位点控制.
- 识别导致超基因等位基因功能差异的突变是具有挑战性的.
- 双性 (dsx) 基因调节昆虫的性差异化,并在Papilio蝶中充当超基因.
研究的目的:
- 阐明 Papilio alphenor 蝶中超基因进化背后的遗传机制.
- 在模仿性和非模仿性表型中确定负责分歧dsx等位基因功能的特定突变.
主要方法:
- 研究了控制 Papilio alphenor.中 dsx 表达的 cis 调节元件 (CREs).
- 分析了DSX转录因子与DSXCREs的结合.
- 利用遗传和分子技术来评估已识别的CREs的功能.
主要成果:
- 帕皮里奥 (Papilio alphenor) 超基因是通过招募六种新型CREs而演变的.
- 这些新的CREs调解了基因基因特异性的dsx表达,控制了不同的雌性翅膀表型.
- 六种新型CREs中的四种被DSX转录因子结合,这表明自我调节.
结论:
- 实验证据支持关于复杂特征进化的经典超基因理论.
- 通过DSX转录因子自我调节可能是超基因起源的关键机制.
- 这项研究突出了如何通过调节性进化将类基因合并到新的发育角色中.
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