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Updated: Jul 5, 2025

Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons
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Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons

Published on: August 16, 2020

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神经元中的构成性内分泌体穿孔允许通过内部化预先形成的纤维来诱导α-Synuclein聚合

Anwesha Sanyal1,2, Gustavo Scanavachi1,2, Elliott Somerville2

  • 1Department of Cell Biology, Harvard Medical School, 200 Longwood Ave, Boston, MA 02115, USA.

bioRxiv : the preprint server for biology
|January 23, 2024
PubMed
概括

神经元具有自然穿孔的内分泌体,在帕金森病模型中促进α-synuclein聚合和细胞死亡. 抑制PIKfyve激酶可以减少这些穿孔,并防止疾病的进展.

关键词:
在Apilimod中使用Apilimod.在PIK中,有五种激酶.帕金森病是帕金森氏症的一种疾病.瓦库林-1是一种真空.阳解体膜的交通流量.活细胞成像技术使用.神经退行症的神经退行症

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