婴儿早期的成长推动了最佳的大脑功能连接,这预测了儿童后期的认知灵活性
Chiara Bulgarelli1,2, Anna Blasi2, Samantha McCann3,4
1Centre for Brain and Cognitive Development, Birkbeck, University of London, UK.
bioRxiv : the preprint server for biology
|January 23, 2024
概括
婴儿早期的成长显著影响大脑网络的发展,并预测了学龄前儿童的认知灵活性. 这凸显了对受逆境影响地区早期干预的迫切需要.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 全球健康 全球健康
背景情况:
- 功能性大脑网络组织,以功能连接 (FC) 来衡量,对于健康的神经发育至关重要.
- 早期的逆境,如营养不良,破坏神经发育和FC,导致较差的长期结果.
研究的目的:
- 纵向评估早期生长轨迹对冈比亚农村人口 (5-24个月) 发育FC的影响.
- 检查早期增长驱动的FC轨迹与学龄前 (3-5岁) 的认知灵活性之间的关系.
主要方法:
- 从5个月到24个月的功能连接 (FC) 的纵向评估.
- 在甘比亚农村群体中对3-5岁的认知灵活性进行评估.
- 分析早期的身体生长轨迹 (5个月前) 以及它们与FC发育的关联.
主要成果:
- 5个月前的早期身体成长与功能连接 (FC) 的最佳发育轨迹有关.
- 这些最佳的FC轨迹预测了学龄前儿童更好的认知灵活性.
- 冈比亚的样本显示,随着年龄的增长,远程半球间FC的衰减,与其他种群不同.
结论:
- 婴儿早期的成长深远影响大脑发育和随后的认知结果.
- 早期成长中断会对大脑网络组织和学前认知能力产生负面影响.
- 针对生命早期成长的干预措施在面临逆境的全球环境中至关重要.
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