通过集体迁移进行非遗传适应.
bioRxiv : the preprint server for biology
|January 23, 2024
概括
细菌群体通过集体迁移快速适应新环境,这丰富了没有遗传变化的高性能游泳者. 这种动态的,非遗传的适应性调整了各种条件的特征.
科学领域:
- 微生物学 微生物学
- 进化生物学 进化生物学
- 系统生物学 系统生物学
背景情况:
- 细胞群通过基因调节,表型切换或突变适应环境变化.
- 现有的适应机制通常在它们可以调整的特征数量上是有限的,或者发展起来很慢.
研究的目的:
- 研究迁徙细菌种群如何调节它们的表型分布以适应不同的环境.
- 识别超越基因调节和突变的新,快速和多特征的适应机制.
主要方法:
- 产生的同源性大肠杆菌菌种群具有不同的游泳行为.
- 在液态和多孔环境中迁移期间观察到的表型分布.
- 在化疗过程中测量化学受体丰度分布.
主要成果:
- 迁移的种群迅速丰富了高性能游泳表型,在没有基因调节或突变的情况下适应.
- 适应是动态和可逆的,发生在几个细胞翻倍时间内.
- 迁移同时适应了多个与化学反应相关的特征,这是由增长产生的多样性和消除表现不佳的表型之间的平衡所驱动的.
结论:
- 集体迁移为细胞种群提供了一个快速,灵活和非遗传的机制,使其表型成分适应不同的环境.
- 这种机制,平衡多样性生成和表型选择,可能是各种生物环境中的通用适应策略,包括微生物群落,癌症和发育.
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