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Updated: Jul 5, 2025

Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43
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从原始抗原性罪恶中替换序列菌株的速度限制

Lauren McGough1, Sarah Cobey1

  • 1Department of Ecology and Evolution, University of Chicago, Chicago, IL.

bioRxiv : the preprint server for biology
|January 23, 2024
PubMed
概括

原始抗原性罪 (OAS) 限制了病原体的进化,防止了无需多样化的连续菌株替代. 这种免疫印记现象对新菌株的出现施加了"速度限制".

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Translesion (TLS) polymerases rescue stalled DNA polymerases at sites of damaged bases by replacing the replicative polymerase and installing a nucleotide across the damaged site. Doing so, TLS allows additional time for the cell to repair the damage before resuming regular DNA replication.
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