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相关概念视频

RNA-seq03:21

RNA-seq

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RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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相关实验视频

Updated: Jul 5, 2025

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
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A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues

Published on: December 5, 2016

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使用半监督学习框架从纳米孔测序检测m6ARNA修饰.

Haotian Teng1, Marcus Stoiber2, Ziv Bar-Joseph1

  • 1Computational Biology Department, Carnegie Mellon Univeristy, Pittsburgh PA 15213, USA.

bioRxiv : the preprint server for biology
|January 23, 2024
PubMed
概括

一种新型的基调器Xron,可以从纳米孔测序信号直接准确地检测RNA N6-甲基氨酸 (m6A) 甲基化. 这种方法克服了数据稀缺性,使得有效的de novo甲基组组装成为可能.

科学领域:

  • 分子生物学分子生物学
  • 生物信息学是一种生物信息学.
  • 基因组学就是基因组学.

背景情况:

  • 直接纳米孔RNA测序提供了一种方法,通过分析电流信号来检测RNA基变异,例如N6-甲基氨酸 (m6A) 甲基化.
  • 这一领域的一个重大障碍是,对于甲基化检测的全面培训数据集的有限可用性.

结论:

  • 训练有素的Xron基调器在读取级和现场级m6A检测方面,与现有方法相比,表现优越.
  • Xron是一个独立的,端到端的解决方案,用于从纳米孔RNA测序数据直接检测m6A.
  • 这项技术促进了新的甲基组组装,促进了RNA修饰的研究.
关键词:
深度学习是一种深度学习.纳米孔测序的测序隐藏的马尔科夫模型m6A 是一种RNA修饰.

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