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相关实验视频

Updated: Jul 5, 2025

Preclinical Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices

Preclinical Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices

Published on: June 16, 2020

使用光学实验创建干细胞衍生的心肌细胞的细胞特异性计算模型.

Janice Yang¹, Neil Daily², Taylor K Pullinger¹

¹Department of Pharmacological Sciences & Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

bioRxiv : the preprint server for biology

|January 23, 2024

概括

这项研究开发了一个计算管道,以校准人类诱导的多能干细胞衍生心肌细胞 (iPSC-CM) 模型,改善对心脏变异性和药物反应的理解.

科学领域:

心脏病学心脏病学
计算生物学计算生物学
干细胞研究干细胞研究

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Subtype-specific Optical Action Potential Recordings in Human Induced Pluripotent Stem Cell-derived Ventricular Cardiomyocytes

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Published on: September 27, 2018

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Last Updated: Jul 5, 2025

Preclinical Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices

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Published on: June 16, 2020

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Published on: March 21, 2025

Subtype-specific Optical Action Potential Recordings in Human Induced Pluripotent Stem Cell-derived Ventricular Cardiomyocytes

Subtype-specific Optical Action Potential Recordings in Human Induced Pluripotent Stem Cell-derived Ventricular Cardiomyocytes

Published on: September 27, 2018

背景情况:

人类诱导的多能干细胞衍生心肌细胞 (iPSC-CMs) 对心脏研究有价值,但表现出不成熟的电生理学和表型变异性.
现有的iPSC-CMs数学模型并不能完全捕捉到这种观察到的变化.

结论:

这种计算方法解决了iPSC-CM电生理学不成熟和可变性.
能够更好地了解不同iPSC-CM制剂中扰动反应的潜在机制.
为疾病和治疗研究提供更准确的心脏建模.