相关实验视频

Updated: Jul 5, 2025

Novel Atomic Force Microscopy Based Biopanning for Isolation of Morphology Specific Reagents against TDP-43 Variants in Amyotrophic Lateral Sclerosis

Novel Atomic Force Microscopy Based Biopanning for Isolation of Morphology Specific Reagents against TDP-43 Variants in Amyotrophic Lateral Sclerosis

Published on: February 12, 2015

在肌缩侧面硬化症中,TDP-43病理联系了先天性和适应性免疫力

Baggio A Evangelista, Joey V Ragusa, Kyle Pellegrino

bioRxiv : the preprint server for biology

|January 23, 2024

概括

交换性反应DNA结合蛋白 (TDP-43) 病理在ALS被免疫细胞内部化,激活先天和适应性反应. 这项研究将TDP-43与ALS免疫功能障碍联系起来,这表明了新的治疗点.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
分子生物学分子生物学

背景情况:

肌缩侧面硬化症 (ALS) 是一种致命的运动神经元疾病,其中90%的患者患有TDP-43病理.
免疫功能障碍越来越被认为是ALS进展的关键因素.
在ALS中调节免疫反应中TDP-43病理的作用尚不清楚.

结论:

在ALS中建立了TDP-43病理和免疫功能障碍之间的新联系.
强调了监测和操纵免疫反应的潜力,作为ALS的治疗策略.
强调了在ALS病变发生过程中免疫反应的转化和诊断含义.

更多相关视频

Use of Capillary Electrophoresis Immunoassay to Search for Potential Biomarkers of Amyotrophic Lateral Sclerosis in Human Platelets

Use of Capillary Electrophoresis Immunoassay to Search for Potential Biomarkers of Amyotrophic Lateral Sclerosis in Human Platelets

Published on: February 10, 2020

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles

Published on: October 18, 2024

相关概念视频

Cell-mediated Immune Responses

Cell-mediated Immune Responses