水平的皮质连接将内在的移动波形塑成特征选择性动机,调节感知灵敏度
Zachary W Davis1,2, Alexandria Busch3,4, Christopher Stewerd3,4
1The Salk Institute for Biological Studies, La Jolla, CA, USA. 92037.
Research square
|January 23, 2024
概括
大脑中的内在移动波 (iTWs) 源于特征选择性的断片连接. 这些波或图案以特征依赖的方式调节神经和感知灵敏度.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
背景情况:
- 持续的皮质活动表现出内在的移动波 (iTWs),影响感官处理和感知.
- 假设反复的水平连接,包括特征选择性的不齐连接,是 iTWs 的基础.
研究的目的:
- 调查特征选择性iTWs,称为动机,是否存在于体内.
- 为了确定皮层斑块连接是否形成iTWs.
- 探索iTW图案如何调节神经和感知灵敏度.
主要方法:
- 开发了一个尖端网络模型 (平衡不一致网络,BPN) 具有特征选择性的不一致连接.
- 在BPN模型中观察到的iTW动机.
- 分析了使用新型波浪模式比较方法从马尔莫塞特区域MT获得的多电极阵列数据.
主要成果:
- 在马尔莫塞特地区MT.中识别了特征选择性的iTW图案.
- 图案在持续的尖端活动中表现出方向选择性调制,与BPN预测一致.
- 动机调节了唤起反应的收益和感知灵敏度,当刺激特征与动机偏好相匹配时.
结论:
- 内在的移动波是由皮质水平连接模式所塑造的.
- 不一致的连接促进了ITWs以特征选择性方式调节神经和感知灵敏度.
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